Wednesday, July 31, 2019

Hudson River: a Detailed and Comprehensive Geological History

Contents Introduction†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 2 Hudson River Formation†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 5 Hudson Canyon†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã ¢â‚¬ ¦Ã¢â‚¬ ¦12 Glacial History†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 14 Conclusion†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦17 Bibliography†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚ ¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦18 Maps & Diagrams†¦.. †¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. 19 Hudson Canyon†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.. 19 Geological Processes†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦. 2 1|Page Introduction In 1872, a naturalist and surveyor by the name of Verplanck Colvin found the source of the Hudson River. It is a small pond on the south western slope of Mt. Marcy, the highest peak in the Adirondacks, called Lake Tear of the Clouds. So little is Lake Tear of the Clouds that if no water was to feed it for seven days it would be reduced to just an empty basin. Nevertheless, the Hudson starts right in its waters. One could say the Hudson River is divided into two distinct sections differentiated by geology and appearance.The first section winds its way through the Adirondack Mountains spanning 166 miles from Lake Tear of the Clouds to the Federal Dam in Troy. This section is un-navigable by boat and in some places somewhat rapid. The second section, which is quite different from the first, starts at the Federal Dam and runs for 149 miles through the â€Å"rolling hills† all the way to the Narrows between Brooklyn and Staten Island. Back up north at Lak e Tear of the Clouds is fed by natural springs and runoff from the sheer steepness of Mt. Marcy and other streams winding down from the high peaks of the Adirondacks.Throughout the whole Adirondack mountain range, the watershed drains and dumps runoff from 3,400 foot peaks into the lowlands less than 410 feet above sea level. From Lake Tear of the Clouds [in the space of a mile] the river drops 1,000 feet down a deep trench to join the Opalescent River1. A bit more southward, the Mohawk River drains much of the runoff from central New York into the Hudson. In fact, over half of the Hudson Rivers water volume comes from the Mohawk, and without it, the Hudson would be practically non-existent.Further south of Albany tributaries flow westward to the Hudson from the Taconic Mountains and eastward from the Catskills. Still further south the tributaries for the Hudson begin to appear rectangular, almost following the trend of the faults and 1 The Opalescent River is not a separate river f rom the Hudson but merely a section named by old Native American tribes. 2|Page ridges that run northeast to southwest of the river while other tributaries join at right angles to the faults along the joint planes.At this point in its path, the river begins to occupy its original bedrock gorge formed millions of years ago, flowing over rock ledge rapids and the coarse cobble point bars2 that are very common from Mt. Marcy to Glens Falls, until it is partially blocked by mountains. It is here that the river makes a sharp turn to the east and flows through the Luzerne Mountain gorge in western New York and then emerges quickly onto glacial lake sediments deposited in the Pliocene Glaciation and forms a very broad, almost meandering path on the lowlands (supported by shale) for the nearly 130 miles to Newburgh.South of Newburgh the river cuts laterally through the hard crystalline rocks of the Hudson Highlands, shifting back and forth in its valley (almost like a cradle) until it emerg es from the highlands and starts to exhibit fjord like characteristics within the towering rock walls around it. The river’s course then slightly curves in front of the Palisades escarpment3, which towers more than 328 feet above the water’s surface. At the Narrows the Hudson breaches its final barrier, the terminal moraine4 of the last glaciation (more on this in the Glacial History section) before it reaches the Atlantic Ocean.At the Atlantic (although tidal) the Hudson behaves as any other river would and deposits its bed load (sediments carried by the river) and some of the fine-grained suspended load (basically fine grained sand and dirt floating in the water) into the form of sandbars. Over millions of years, these have contributed to building up many islands including Staten Island, Hoffman Island, Swinburne Island and many others. The very low slope of the Hudson plays a great role in the amount of discharge and island buildup, too, as it only rises about 0. 4 inches per mile for the last 150 miles of the rivers path. To give some perspective, the Mississippi river rises approximately 6 inches per mile during its course, and discharges about 700 million tons of sediment per year into the Gulf of Mexico 2 Coarse cobble point bars are essentially pointed cobble that has been piled into bar like formations. These formations are generally formed when sediments carrying cobble leave it behind. 3 Ground formed into a steep slope as part of fortification. â€Å"Moraine† is a word used to describe the earth, stones and debris a glacier deposits. â€Å"Terminal† describes that these items were deposited where the glaciers maximum extent was, in this case Long Island. 3|Page and its mouth is approximately a ? -mile wide. The Hudson River discharges about 175 million tons of sediment per year and its mouth is about the same width at a ? mile. With a 2 inch increase in slope geologists predict the discharge rate of the Hudson would spik e up to about 450 million tons per year and the mouth of it would close up to about 250’ wide.This would place Manhattan underwater and greatly limit boat traffic as well as make Long Island more of a true island separated from land by at least 3 miles or so of water5. And so, the geography of the Hudson River today ends here in Manhattan, but the geology of what lies underneath is much more important. Continue reading if you must, and dwell into a mystery of time and a lot of pushing and pulling. 5 Do not worry about this happening now though because the rivers overall slope has not changed more than a centimeter in the last couple thousand years and shows no signs of speeding up. 4|Page Hudson River FormationThe Geology of the Hudson River is complex. Billions of years of folding, pushing, pulling, separating, and moving have formed, deformed and reformed the Hudson River valley into what it is today, a â€Å"giant palimpsest6, a great parchment on which the hand of nature has written and rewritten her bold signature for more than a billion years†7. In the next section, I am going to attempt to condense over a billion years worth of Geologic History into less than ten pages. Despite complex knowledge and strange words it is a simple story of time and rocks, moving and changing: the formation of the Hudson River and its valley.The Hudson’s geological â€Å"personality† very much reflects its structure and the changes made on it, underneath it and all around it from the Pleistocene glaciations8 . The bedrock foundation of the Hudson was established in the space of three oregany’s (mountain building periods) beginning over a billion years ago. These mountain-building episodes re-triggered long intervals of underground erosion and periodic submersion by the epicontinental seas (or oceans) to help start forming the Hudson River Valley. At a point much later in this story, glacial erosion reshaped the landscape of the HRV into wh at it appears as today.The first major mountain building episode, the Grenville Orogeny began about 1. 2 billion years ago. It was one of the biggest Oregany’s and affected a broad region along the coast of what was Ancient North America, from the northeast waters of Canada to northwestern Mexico. The mountains created by the Grenville Orogeny were most likely as tall as or taller than the Himalayas and were driven to these heights by a collision of Laurentia (Ancient N. America) and Gondwana (Africa) in which Gondwana overrode Laurentia. The deep burial of Laurentia resulted in the first 7 Written upon, or engraved on more than once. The Hudson: A History, Chapter 1: The River and the Land, pg. 10 8 A period of ice buildup to form glaciers, or the act of glaciation. 5|Page metamorphism, partial melting of rock and the separation of the light and dark minerals found in the Adirondack gneisses9. Many hundred thousand of years later in the Proterozoic period as the continents p eriodically moved, basaltic volcanic rocks merged into the mountains cutting the anorthosites10 and gneisses laterally across.These gneisses are around one billion years old, while the Highland gneisses may be a bit older. The Fordham gneisses are the youngest and can be dated to just under a billion years old. Over the millions of years, long episodes of erosion on the Grenville Mountains and constant lifting of the crust have brought it to the surface. Later in the Proterozoic period, erosion of this crust formed and provided a thick source of sedimentary deposits that partially submerged the upland area of coastal Laurentia (presently this is the area south of and parallel to the Appalachian Mountains).These deposits are now found mostly in the Appalachians, with almost all of them have been removed from the Hudson valley, leaving hard rock and clay for the Hudson River to rest on. In the early Paleozoic, the sand and gravel that was eroded from the mountains during the Proterozo ic period became basal sandstone and conglomerate11, which is more commonly known as the Potsdam Sandstone in northern NY and the Lower Quartzite that is prized throughout the Hudson Highlands.As the Epicontinental sea inundated this (once) mountainous region the sandstone and Lower Quartzite were buried under a thick cover of marine limestone and shale, which was laid down in an elongated trough that formed on the continental shelf where mountains had once been. The limestone was mostly deposited on the shallow edges of the trough while the shale solidified from the mud carried into the deeper seaward part of the trough. The solidified shale then created the bedrock between Glens Falls and the Highlands. 9Coarse, grained metamorphic rock composed of quartz, feldspar and mica. An igneous rock made up largely of soda-lime feldspar. 11 Rock composed of rounded fragments of various rocks cemented together in a mass of hardened clay and sand, like a composite. 10 6|Page In the Late Camb rian period,12 Laurentia once again collided, but this time with the ancestral core of Europe, Baltica and a large fragment of what is thought to be the continental crust known as Avalonia. This started the mountain building period known as the Taconic Orogeny, which lasted throughout the Ordovician Period.The Taconic Orogeny also resulted in the new supercontinent Laurasia. While much of the activity involving this collision took place well to the east it also affected the HRV. Island arc volcanic structures such as the Cortlandt Complex have been found in the Hudson Highlands. To the North and West in the mid-Hudson Valley, the sedimentary rocks that were deposited in the early Paleozoic Period were folded (with the trend of the folds and faults already in place) parallel to the southwest to northeast facing the Appalachians.These folds and faults eventually became some of the paths of the HRV tributaries. Closer to the coast than these faults, thin sheets of rock were pushed seve ral dozen miles west. This event is known as the Taconic Thrust and took place in the area where today exists the Taconic parkway. Because of this event, the fine-grained shale that was there was crumpled (as if we crumple paper) and pushed into the narrow channel of water west of the mountains near present day Croton. Over many years thereafter blocks of limestone into the channel and were merged into a jumble of shale clumps.Today millions of years later the river flows past the western edge of the channel and then cuts into the disorganized deposits of shale as it continues south. As we travel through time, sandstone, limestone, shale and Proterozoic bedrock from the Hudson Highlands became buried as Laurentia’s coastal margin was subducted13 close to where it and Europe’s plates met. The rocks that met each other from each plate partially melted and transformed into more gneiss, marble and schist14, which was then folded and moved once more to be in alignment 12 00 million years ago Subduction can be described as the action or process in plate tectonics of the edge of one crustal plate descending below the edge of another, almost like a controlled earthquake. 14 Schist is a metamorphic crystalline rock that has a closely foliated structure and can be split along approximately parallel planes. 13 7|Page with the Appalachians. This set the stage for the modern day continental shelf to form, although it would take millions of more years for it to happen. After the two plates of Europe and Laurentia collided, there was a sort of lull in activity around this area.This allowed streams in the lowlands to follow the valleys formed along the fault lines, or on the softer marble layers around Manhattan. The oceanic crust borders and the rocks around NYC and to the east more or less contained the streams around Manhattan, while the streams in the lowlands and around our area were free to roam and spread out. After the Taconic Orogeny ended, a long inter val of erosion began stripping away the excess crust as the â€Å"new† continent (modern North America, or Laurasia) was very slowly lifted by the compression of the plates.As the upland area was eroded away the epicontinental sea gradually filled the Hudson Valley region from the low lying land of the coastal margin all the way west nearly three-quarters of the way to Pittsburgh. Later during the Silurian and into the early Devonian period shallow seas covered the area and left behind calcium carbonate sediments making the soil very rich. At around the same time rivers formed and flowed from the uplands carrying major amounts of sediment west to the sea to form marine sandstone.While the marine sandstone was being formed, at the shoreline a large delta15 formed over the junk that the marine sandstone left behind. By the midDevonian period, an alluvial plain16 had reached across much the western Catskill region and the shoreline had shifted slightly west about 15 miles or so. At this time, thousands and thousands of feet of sediment from mid-Paleozoic times were piled up over the Hudson Valley and continental red sandstone (one reason why there is so much sandstone around here) from farther east inland were incorporated with the gray marine sandstone from the west closer to the coast.The force of all this happening at once overturned the folds that were in place to the northwest (near present day Schunemunk Mountain along the NYS thruway near Highland Mills) exposing the limestone that 15 A Delta is a triangular alluvial plain, usually where a rivers mouth is. A level or gently sloping flat or a slightly undulating land surface resulting from extensive deposition of alluvial materials by running water 16 8|Page was buried slightly underneath the sediment that had accumulated over the years. This marked the end of the Devonian Period, and the start of the Acadian Orogeny.The Acadian Orogeny began as the North American plates started to compress again and lift up the eastern mountain ranges around New England and western Pennsylvania. This Orogeny was also partially caused and linked to the collision that happened between Laurentia and Gondwana that created Laurasia, and most likely, if this Orogeny had not happened the Hudson River would be a completely different river, and possibly would be connected to the Mississippi River. As the plates began to compress each other again they created volcanic arcs and granite intrusions somewhat east of the Hudson Valley near the coast.Around this time in our little history story the seas started to retreat from the east to west and started to expose the incredibly thick layer of sediment and rocks from the Acadian Mountains all the way to the Catskills. The final compressions dating back to the Paleozoic era continents and the Alleghenian Orogeny now ended and the earth came together to form Pangaea. Because of all this land being pushed up, the Epicontinental Sea retreated from the Catskills to the Poconos in Pennsylvania leaving much of New York and New England dry once again.Now above sea level the strata from the Devonian period became subject to erosion for 250 million years. At some point during this time, the drainage patterns shifted and aligned the ancient Hudson River along a NorthSouth line much like it is today. This was the biggest directional change the Hudson ever underwent. As the strata and sediment were worn away from this new path of drainage, it revealed the granite, marble and schist underneath which became the building materials for our modern world.With the Taconic Mountains now more to the east and the Catskill Mountains to the west the Hudson worked its way down deep into the sediment it was on top of leaving behind a hard bedrock base nearly 5,000 feet deep in places17. This created a solid foundation and left the Hudson with a relatively stable path 17 Over the last several million years, and an Ice age this has all been filled in and now the H udson has an average depth of 32’. 9|Page that has not changed tremendously since. The breakup of Pangaea followed soon thereafter and the coastline of North America began to resemble what it is now.At the same time, the Hudson was filling its banks; basaltic magmas were merged along the fault lines and into the bedrock forming the Palisades Sill18. After that, compression and buildup of sediment and rock slowly built the Palisades up. Today the part of the Palisades that stands is almost like a canyon above the Newark Basin. The â€Å"tabular†19 Palisades still slope to the west, and the eastern edge forms the escarpment, or â€Å"palisade†20 21 of rock joined vertically that we recognize today from miles around New York and from the air as we fly to new places and heights.But to learn how, we must travel to another time in this story, the Mesozoic Period. Some time in the late Mesozoic period, igneous rock deposits were moved yet again and placed along a line going Northwest to southwest from Canada to New England lifting the mountains in its path by several hundred feet and in some cases over 1,000 feet. Because, as you might infer, rock takes up space, and as it lifted up the mountains and separated them, it started to separate North America’s continental plate away from the mid-ocean ridge22 and over a very hot area above the earth’s layer of magma near where the present day Appalachians exist.This caused what geologists think was a shot of magma that melted through that particular part of the plate (which was quite thinner than today) and uplifted the Northern part of the Appalachians. This, in turn reactivated erosion and brought the domed like anorthosites to the surface which is most likely the reason that the Appalachian Mountains are not scraggly and sharp like the Alps, but more rolling with large boulders and open expanses of rock. The Catskills and Adirondacks also experienced lifting, but in a much smaller amou nt. Almost at the same time as all this uplifting was happening, a 18 19Think of this as the palisades foundation. L. Sirkin & H. Bokuniewics – The Hudson River Valley: Geological History, Landforms, and Resources pg. 17. 20 L. Sirkin & H. Bokuniewics – The Hudson River Valley: Geological History, Landforms, and Resources page 17 21 Palisade literally means â€Å"a fence of stakes for defense† The Palisades are called the Palisades by Native American Tribes because they helped as defense for them from other tribes. 22 The mid-ocean ridge is a undersea mountain ridge that is where the North American and European plate meet. While this ridge has hardly ever changed, the plates do move.In this case it is the biggest moves it has ever made. 10 | P a g e hole began to form from sinkholes on the western slope of Mt. Marcy and soon filled with water. This was Lake Tear of the Clouds. After Lake Tear of the Clouds formed and filled with water, the Newark basin reached i ts fullest capacity of water and the Hudson began to â€Å"drive† into its flood plain and carve out its gorge in the gneisses of the Highlands of southern New York. This area is now mostly between West Point and Hastings on Hudson, but it continues as a much smaller â€Å"weaker† gorge almost down to Fort Lee.The Hudson was now a true river, but would still undergo massive changes over the next several million years. At this time in the Hudson River’s history, Long Island did not exist as what it does today. It was a tiny, almost alcove piece of land that was in no way an island. In addition to that, there was no opening to the Atlantic for the Hudson. At the place where the Hudson empties into the Atlantic at the Narrows was a big solid mass of land. The Hudson by definition was a lake. So, as the Hudson filled up and he water put immense pressure on the piece of landmass blocking it from the Atlantic it began to carve out and widen an outlet. It took only a f ew hundred years23 for the Hudson to make it to the Atlantic, bringing with it thousands upon thousands of tons of sediment that had piled up in the Newark Basin. This created the new continental shelf to form the coastal â€Å"plain† we see today that stretches for about a hundred miles out to sea from New York, only in that time and age it stretched for nearly 425 miles, nearly halfway to Bermuda.The Hudson now had an outlet, and the waters started moving south digging, and bringing sediment to the mouth building up Long Island a little bit24, as well as separating it from the mainland with what is now the East River. The sea levels around North America also dropped a few centimeters as the waters made their way up the Hudson forming the Hudson River estuary. This raised the Hudson’s waters by a few centimeters and created its almost permanent banks that have 23This is an extremely short time in geologic history and greatly shows how much the pressure was on the land mass blocking the Hudson from the Atlantic. 24 Although Long Island did get built up at this time, the majority of it was built up during the last ice age nearly 20,000 years ago. 11 | P a g e not changed very much since. Because the sea levels were much lower in that time period the Hudson also began its excavation of the Hudson Canyon with the help of the naturally occurring currents (more on this in the Hudson Canyon section) and more than doubled its length to nearly 895 miles (about 1,440km) long.After nearly 500 million years the Hudson rivers formation had ended and all that was left to change it was its own water wearing away at its bottom and a glaciation that would come in a few million years. Hudson Canyon The Hudson Canyon is possibly the biggest mystery of the Hudson River. How did it form? When exactly did it form? Why did it form? These are all questions geologists and hydrologists ask when looking at it. Most people in fact have never heard of it. To them the Hudson is a river that starts in the Adirondacks and ends at the narrows.To the few that know of the Hudson Canyon, the Hudson River starts in the Adirondacks and ends nearly 925 miles south halfway to Bermuda right after falling over a half mile down a [now] underwater canyon and then fanning out and spreading to the Atlantic Ocean. There, even though underwater it still carries small amounts of the Hudson’s freshwater (out to sea), and most geologists still consider it a part of the Hudson. This makes the true length of the river from Lake Tear of the Clouds to the end of the Hudson Canyon 922 miles, more than double of what we consider the â€Å"Hudson†.As explained in the last section (Hudson River Formation) in the late Mesozoic Period the Hudson River broke the land barrier that held it from emptying into the Atlantic. When it broke the barrier it began to carve a new path out to sea towards Bermuda. At some point, it reached the Continental Shelf and dug into it creati ng a canyon that eventually connected the shelf to the ocean basin, which is about 1. 5-2. 5 miles deep. Technically the canyon begins as a natural channel many miles wide at the mouth of the Hudson in a depression about 12 feet deep in the rivers bed. It 12 | P a g e ontinues then through the Hudson channel and under the Ambrose light25. Soon after the Ambrose light, it reaches the shelf and goes through the real canyon part of it that is called the Hudson Canyon proper. The Hudson Canyon proper is located about 100 miles east of Battery Park City and has walls almost ? mile in height, which can be compared to the Grand Canyon whose cliffs are about 1-1/8 mile deep. The Hudson Canyon is the largest â€Å"submarine† canyon in the United States, partially due to the currents that pass over, and carrying away sediment and rock, thus carving it deeper and deeper.Over the past 30 years since it was discovered, tracking equipment has logged a nearly 12-inch change in its depth and width making the Hudson Canyon also the fastest growing canyon in the Atlantic Ocean. At the same time it is growing wider and deeper, it is also getting closer to the magma underneath and behind the continental shelf. In simple terms, one day in the next couple hundred or thousand years it will break through and magma will come out creating a new island, possibly connecting the East Coast of the United States with a land bridge that extends more than halfway to Bermuda.Many tributaries around the canyon would be raised by the magma, creating a new network of rivers and streams on the land bridge that could host many kinds of wildlife as well as marsh like environments. In addition to this, the Hudson Canyon has large stores of methane hydrates which according to scientists is a very promising clean burning natural energy source, and could help reduce oil consumption. It is a Canyon of great importance to the Hudson River, and also a big clue into the Glacial history surrounding th e HRV. 25The Ambrose light is the site of a Light House that ships going into the New York Harbor and other harbors in the area use for navigation purposes. 13 | P a g e Glacial History The Glacial History of the Hudson River is probably the one of the most important geological event that happened in the Hudson Valley in the last 50,000 years. Evidence points mostly to the Pleistocene Glaciation, which was the last and only Glaciation to reach this far south into the United States for the change that happened on the Hudson River since it was originally formed.The topography of the Hudson Valley enabled the ice from the Pleistocene Glaciation to form a Lobate Ice margin26 about 50 miles north what is now Manhattan long island. Around 22,000 years ago the Ice over the Catskills and Taconic uplands thinned, while it thickened in the Hudson Valley and expanded southward closer to the mouth of the Hudson. Scientists today doing Pollen analysis and radiocarbon dating have found that the c limate back then right before, and as the last Ice age started was much warmer than today. As one can expect, warmer conditions meant more plants, and the sea level was much higher than today27.When the climate cooled and the Glaciers expanded south all these trees, plants and debris were ground down and immense pressure pushed them into the ground, almost dissolving them into dirt. This not 26 Lobate means resembling of a lobe. In this context it is used to describe the shape of the edge of the Glacier, or its maximum extent which was a short of lobe shape. 27 Evidence shows that the waters might have been as far north Albany. 14 | P a g e only made the area much more barren, but also flattened the Adirondacks, and Hudson Highlands down many thousands of feet.The glacier continued to expand 26,000 years ago and merged with smaller glaciers up north to form one big glacier known as the â€Å"Laurentide Glacier†28. This Glacier covered all of Ontario, the St. Lawrence River, M anitoba, Nunavut, and parts of Quebec, as well as the Great lakes down to Chicago where it almost ran parallel to the US/Canada border before dipping slightly down towards present day Manhattan and following the coast of the US up north. At the height of this glaciers advance the ice most likely was more than 1,000 feet thick over the tops of the Appalachians (if you do the math this means that it was over 1. miles deep) meaning immense pressure was being placed on everything flattening the landscape. This also meant that because there was so much pressure, and the water of the Hudson never froze 100%29 the Hudson’s waters literally pushed the earth and carved the floor of the Hudson to a depth similar that of what it was before it broke its barrier at the Narrows. 30 The dirt being compressed turned back into soft metamorphic rock, and created marble where none existed near Warrensburg.A few miles south at Glens Falls the Ice naturally deepened because of the drop in elevati on and gained momentum31 carving out the fjord previously made even bigger, which created Storm King, Beacon and Bear Mountain. All this rock carved out of the Fjord eventually made its way south where it was dumped over Manhattan and Long Island, somewhat accounting for all the Limestone and shale and schist around that area. At this time, the Hudson Canyon was also carved out by the glacial ice melt flowing through it with rocks and debris and became much deeper and wider.When the Laurentide glacier made it to the Narrows its front stopped moving forward, but its back kept on moving forward compressing everything together (Like an accordion) and melting a lot of the ice. Why this happened is not really known by Scientists because glaciers can float. This area became the Glaciers â€Å"dumpster† and the Terminal Moraine was officially formed. Long Island was 28 29 Yes, it was named after Laurentia, ancient North America. Meaning the whole time there was a glacier over this a rea, the Hudson was still flowing but now mostly with ice melt from the glacier itself. 0 Of course this all filled back in as the glacier melted. 31 A glacier is always moving, whether it is 1 foot a year or 1 inch a year. 15 | P a g e built up and out to its current state and the Moraine extended west into New Jersey and Pennsylvania, carrying with it glacial melt creating many of the glacial lakes in that area such as Lake Hackensack, Glacial Lake Hudson and many others. Clay also being carried was dumped all over the region (mostly on the current Rockland County side) and created a nice thick, slippery layer on which the glacier to slide on.This process of dumping and melting continued for many thousand years and started the recession of Laurentide. In a 2,000 year period from 26,000 years ago to 24,000 years ago Laurentide melted and receded so that all of Long Island, Staten Island, New Jersey, Pennsylvania and pretty much everything south of present day Hartford Connecticut w as ice free. The Ice continued to melt over the next 4,000 years until everything south of Glens Falls was free of ice. The ground, sort of like a sponge when you fill it with water, rose a few meters and went nearly back to its state before the glacier.At Glens falls The glacier stopped for a thousand or so years and slowly melted providing the Hudson valley with a constant stream of fresh glacial water. Around 19,000 years ago the glacier started to recede from Glens Falls and the melt water created Glacial Lake Albany which continued to grow throughout the next several thousand years as Laurentide receded. At 15,500 years the Climate suddenly got cold and the glacier advanced back south to near Poughkeepsie and created the Wallkill, Poughkeepsie, Red hook, Hyde Park ad Pine Plains moraine.As suddenly as the Climate got cold, it got warm again and by 13,000 years the glacier was receded north of present day Quebec City. When the climate got warmer again the sea levels rose, this t ime to near Albany, and caused Glacial Lake Albany to drain. For the next couple thousand years as the climate cooled, the Hudson was tidal up to Poughkeepsie and as the Sea retreated. This brought the tides down with it to near Peekskill where it stayed for many thousands of years until around 6,000 years ago it began to go north to nearly 20 miles past Troy32 by 2,000 years ago the sea was at its present place, and the Hudson was in its present 2 The exception to this is the Troy Dam; if it wasn’t built the Hudson would still be tidal nearly 20 miles north of it. 16 | P a g e state. Long Island was as it is now, and the coast was pretty much the same besides what natural erosion as taken away since then. This was the final Glaciation, and the final change to the Hudson River. After nearly 1. 2 billion years, several different Oregany’s, Hundreds of changes, 4 different climate changes and a whole lot of pushing and pulling and moving the Hudson River was finished bei ng formed and all it needed was for Henry Hudson to come sailing to name it†¦. ConclusionIf you have gotten this far along into this history story then you will know that the Hudson River didn’t just appear, it doesn’t formally end at the Narrows between Brooklyn and Staten island and it isn’t just a river. It is the culmination of 1. 2 billion years (and counting) of the earth doing its shtick33 on the world we live on. It took 7 different continents to pull this off, and it worked out beautifully creating a river of outmost importance to our lives, lives before us, and lives to come. I like most of you out there reading this paper did not know a thing about the Geology of the Hudson River when I started this project.It probably took me a proportionate amount of time to learn this as it did to create the whole Hudson. Now, after early 3 months of reading words I don’t know, looking at diagrams I can’t even understand and writing technical ter ms that I can’t pronounce I have learned what it took, and takes to create the Hudson. Like they say, it takes a village to raise a child; it took a whole world and 1. 2 billion years to create this river, a river of small nature compared to others around us such as the Nile, or Amazon which are nearly 5 times the length of the Hudson and took a very disproportionate amount of time to create. 3 â€Å"Piece†, or â€Å"thing† in Yiddish 17 | P a g e So, as I leave you with this 20 page Essay, think about the next time you go to the Hudson and pick up a handful of sand, and know, just know that that handful of sand has been moved around for 1. 2 billion years to end up at your feet. Bibliography L. Sirkin & H. Bokuniewics (2006) – The Hudson River Valley: Geological History, Landforms and Resources Wikipedia (http://en. wikipedia. org/w/index. php? title=Hudson_Canyon&oldid=453958227) – Hudson Canyon Data SIO, NOAA, U. S.Navy NGA, GEBCO (2010)  œ Google Earthâ„ ¢ United States Geological Survey (USGS) (2004) – Sea Floor Topography & Backscatter Intensity of the Hudson Canyon Region Offshore of New York & New Jersey (http://pubs. usgs. gov/of/2004/1441/html/interp. html) Phil Stoffer & Paula Messina (2008) – Introduction to the Geologic History of the New York Bight (http://www. geo. hunter. cuny. edu/bight/Geology. html) Phil Stoffer & Paula Messina (2008) – The Highlands Region (http://www. geo. hunter. cuny. edu/bight/highland. html) R. G.Wilkins Booth (1970) – The Ontario Water resources commission Geology of the upper part of the Severn River basin and the Severn River basin lying within the Hudson River Lowlands. Steven H. Sehimmrich – Geology of the Hudson Highlands Region (www. environmentalconsortium. org) Access Genealogy – Geology of the Hudson (http://www. accessgenealogy. com/newyork/hudson/geology_hudson. html) Charles Merguerian (2010) – Geology 133 Field Tr ip 18 | P a g e Dick Goodman (2013) – Geologist in California, gave much information and advice on this project United States Navy Geological Services (2013) – Maps, Graphs Bradford B.Van Diver (1985) – Roadside Geology of New York John F. Shupe (1996) – National Geographic Atlas of the World Revised sixth edition Kevin Hile (2009) – The Big Book of Answers Tom Lewis (2005) – The Hudson: A History Maps 19 | P a g e The maps presented here on the next couple of pages are all ones used in this essay as reference. They are from many different sources and show many of the things I talked about, visually. Hudson Canyon 20 | P a g e 21 | P a g e 22 | P a g e Geographical Diagrams 23 | P a g e 24 | P a g e 25 | P a g e

Tuesday, July 30, 2019

Notes on Society

Chapter 10 Social Stratification: a system by which a society ranks categories of people in a hierarchy, it is a trait of society, found in all society's, carries over from generation to generation and creates systems and class Social Mobility: a change in position within the social hierarchy Caste System: Closed system based on ascription, or birth, little or no mobility, shapes a persons entire life, occupation and marriage. Found in traditional Agrarian societies. Class System: social stratification based on both birth, ascription and individual achievement, meritocracy.Meritocracy: Social stratification based on personal merit Status Consistency: the degree of uniformity in a person's social standing across various dimensions of social inequality. Example: A college professor with advanced degrees enjoys high prestige but only earns a modest wage. Structural Social Mobility: a shift in the social position of large numbers of people due more to changes in society itself than to in dividual efforts Ideology: cultural beliefs that justify particular social arrangements, including patterns of inequalityDavis Moore thesis: A system of unequal rewards is necessary to place talented people in the right jobs and to motivate them to work hard. the functional analysis claiming that social stratification has beneficial consequences for the operation of society Blue Collar occupations: lower prestige jobs that involve mostly manual labor White Collar occupations: Higher-prestige jobs that involve mostly mental activity Socioeconomic Status, SES: a composite ranking based on various dimensions of social inequalityConspicuous Consumption: Buying and using products because of the â€Å"statement† they make about social position Chapter 11 Income: earnings from work or investments Wealth: The total value of money and other assets, minus outstanding debts Intragenerational Social Mobility: a change in social position occurring during a person's lifetime. Intergenerati onal Social Mobility: upward or downward social mobility of children in relation to their parents Feminization of Poverty: the trend of women making up an increasing proportion of the poor Chapter 12Global Stratification: Patterns of social inequality in the world as a whole High Income Country: nations with the highest overall standards of living Middle Income Country: nations with the standard of living that is about the average for the world Low Income Country: nations with low standard of living in which most people are poor Modernization Theory: is a model of economic and social development that explains global inequality in terms of technological and cultural differences among nations Dependency Theory: explains global inequality in terms of the historical exploitation of poor societies by rich ones

Monday, July 29, 2019

A Drug in A Box Research Paper Example | Topics and Well Written Essays - 1750 words

A Drug in A Box - Research Paper Example The researcher states that the biomedical engineering field has for a long time experienced difficulties in relation to drug delivery and circulation in the body. However, origami, through simulation of DNA patterns, has proved to be a potential solution to the problem. While people previously practiced origami as a way of activating their brains, enhancing sequencing skills, eye-hand coordination, and mathematical reasoning, it is so appealing that today, it fosters biomedical reasoning and fervently contributes to the proficient and operational delivery of medical or health services. According to Erdmann and Barciszewski, medical and drug research have led to the creation or rather production of thousands of drugs that have revolutionized the treatment of infections including diabetes, cancer, and asthma. While drugs have the potential of changing the functioning of our bodies, the effectiveness of the drug, other than only being presented inapposite concentrations, depends on wher e it acts on, a more reason why paramedics strive to ensure that the drug reaches the targeted organs or spots. Moreover, the cell membrane is involved in the transfer of drugs as absorption, dissemination, and metabolism involves passage across the membrane. Other than the chemical characteristics and manner of administration of the drugs, the shape and molecular size of the drugs also affect its delivery in the body leading to delayed or hampered intended actions or reactions. The movement of drugs in the body is also significantly hampered by the intestinal epithelium, leading to drug wastage and consequently loss of lives as ailments persist without being refuted.

Sunday, July 28, 2019

Substance of Reality Essay Example | Topics and Well Written Essays - 1250 words

Substance of Reality - Essay Example Another early philosopher of repute that grappled with the scientific explanation of what the substance of reality really was is Heraclitus who argued that all reality is involved in an ever-shifting flux (Solomon, Martin & Higgins 51). Precisely, Heraclitus argued that no one could ever step into the same river twice. Democritus, on his part, reduced all reality to an inestimable number of imperceptible and inseparable particles known as atoms, which are always moving in the emptiness and bumping into each other as if to combine but then separate. Just like the cosmological speculators, the Sophists also sought alternatives to thinking that was enshrined in authority, tradition and mythology; this established the foundation for two of the greatest ancient Greek philosophers ever known to this day, Plato and Aristotle. While Plato was Socrates’ greatest brainchild and student, Aristotle was Plato’s most famous student. Aristotle also mentored the greatest and most succe ssful conqueror and ruler ever known, the one and only Alexander the Great. Plato had political links both to the oligarchy and democracy and like Socrates, who participated in a discursive practice with his contemporaries challenging them to critically examine their ideas and beliefs, he believed in the prominence of virtue. Socrates taught all his students including Plato that every man was obligated to discuss virtue daily especially because a life that is not examined is not worth living at all. Socrates was largely opposed to the Sophist’s relativism and skepticism. Nevertheless, Socrates also emphasized values rather than physical science like Sophists, unlike other philosophers that came before him. Aristotle points out that Socrates emphasized questions of morality and specific definitions. Granted that Plato was thoroughly enchanted by Socrates’ teachings, it is often felt that his philosophy is a synthesis of the system of critical inquiry he inherited from h is teacher, the Socratic thought he adopted.

Saturday, July 27, 2019

How can a BMW franchise create Customer Engagement through Social Research Paper

How can a BMW franchise create Customer Engagement through Social Media - Research Paper Example According to the research findings the reasons behind the utilisation of the social media sites depend upon multifarious factors. Its utilisation may depend upon components such as company profile, products and customers that the company is serving. Social media websites can be considered as a good way through which the dependability as well as the goodwill of a company can be enhanced. People make use of social media sites for certain reasons such as for the purpose of interacting, collaborating, looking for counsel from the experts, disseminating of the multimedia, looking for opinions, contributing reviews as well as entertainment. Most of the people argue the fact that social media tends to bring a new sense of community by permitting them to connect with those who are similar to themselves i.e. like-minded people and people with similar tastes and preferences. A number of people are making use of the social media while initiating purchase decisions. The figure below demonstrates the use of social media by BMW and others and the benefits obtained by it in order to gain higher return on investment. The figure makes it apparent that BMW scores high in terms of revenues earned by making use of the social media. It is a well known fact that the new media environment is featured by interactivity and multi-dimensional communication flows. With the pace of time, the marketing functions have also started incorporating social media in its campaigns. (Yamamichi, 2011). The increased utilisation of social networking sites such as Facebook as well as Twitter in order to market the products as well as the services is gaining huge attention in the recent times. The companies make use of the social media sites as one of the significant communication channels so that they can gain feedback of the consumers. It has been recognised that on-line communities are considered as a vital component of social media since they offer the companies with cross-selling opportunities to v arious user groups sharing the similar platform (Donath, 2004). Social media can offer BMW with immediate feedbacks and present the company with quick indications regarding what is required in order to resolve pertinent issues. In the present times, the companies make use of the social media so that they can improve their marketing schemes. The purpose of social media must be to improve branding of the business of BMW and to increase the popularity of the product. It can be mentioned that the social media must also be utilised for the purpose of tracking the presence of the business online in order to ensure that the clients are not deteriorating the value of the brand (Zwart, Lindsay, Henderson, & Phillips, 2011). Certain authors have stated the fact that one of the main benefits of social media is to identify precisely regarding what the customers are thinking. Businesses also make use of the social media sites in order to increase the sales of the products and the services and in turn to increase the market share (Ali, 2011). Social media makes it easier for the companies to create relationships, position the brand properly and share exciting experiences and information with their customers (National Association of Insurance Commissioners, 2011). Web Users Frequency It has been found that the rate of internet penetration in Europe in the year 2011 had been 61.3% while the world average was 32.7%. Internet penetration in rest of the world has been 28.9%. The figure presented below helps

Business Communications Assignment Example | Topics and Well Written Essays - 750 words

Business Communications - Assignment Example Employee Concerns ïÆ'Ëœ Segregate and classify technical support staff according to educational background, length of service, and skills in addressing technical support and client concerns. Those who had been with the company for more than five years should address more advanced concerns of clients regarding technical difficulties and problems being encountered. Those who are newly college graduates and have been with the company for less than one year should address basis inquiries and client concerns. The entry level technical support staff should therefore receive more training on issues regarding technical support and customer service satisfaction. Those who had been with the company for more than 5 to 10 years should be evaluated for promotions to supervisory or managerial positions. ïÆ'Ëœ Implement regular performance evaluation that would be the basis for promotions or sanctions, as needed. Those found to be consistently friendly, accommodating, and assists clients and colleagues must be promoted and rewarded. Those who are found to be rude should be sanctioned (reprimand, warning) and be subjected to further training on technical support and customer service, as needed. ïÆ'Ëœ Provision of rewards and promotions; as well as sanctions and penalties, would address issues such as rushing out as soon as the workday ends and failure to address and endorse clients’ concerns.

Friday, July 26, 2019

Concert Review Essay Example | Topics and Well Written Essays - 500 words

Concert Review - Essay Example The combination of these four elements allow for a truly powerful musical connection with the audience. The Celtic Women sung a Capella, with the added orchestra and percussion section beautifully. Some critics have criticized the Celtic Women for using prerecorded music for some of the orchestra. I personally could not tell a difference. The orchestra preforming on the albums is large. It would be impossible to make an orchestra that large to tour on a busy schedule like the Celtic Women have. The live orchestra preformed flawlessly. The prerecorded music did not detract from the overall show. The two songs I enjoyed the most were â€Å"Danny Boy† and â€Å"Somewhere Over the Rainbow†. These two songs were my favorites, because I have heard them a million times. From high school performances of â€Å"Danny Boy† to Judy Garlands rendition of â€Å"Somewhere Over the Rainbow†, I have heard these two songs in a variety of ways. The Celtic Womens performance of these numbers have to the best I have ever heard. The soul wrenching emotion placed into each song made me feel true sorrow and hope. One does not just listen to the Celtic Womens music, but feels it as well. The atmosphere of the Celtic Womens concert was also magical. Lights were raised and lowered flatteringly on the Celtic Women, chorus, and orchestra. The costumes of long flowing dresses gave the women an appearance of floating on air. The fiddlers costume was the most amazing, although like the other Celtic Women, this dress allowed her to dance and fiddle at the same time. The effect was like a fairy dancing across the stage. Smoke surrounded the orchestra, giving off a misty Celtic feel. The whole event was magical. Many critics have argued that the Celtic Women are not authentically Celtic, since they play modern songs like â€Å"Somewhere Over the Rainbow† or even songs with Christian

Thursday, July 25, 2019

Assessment 1 The Report supply chian magement (SM2038) Essay

Assessment 1 The Report supply chian magement (SM2038) - Essay Example Supply chain management is deeply involved in the successful achievement of desired levels of productivity and profitability by any company or organization. One of the key factors of supply chain management process is purchasing. Gadde and Hakansson (1993) found that purchasing is seen as one of the key strategic functions to be performed by the management of any organization in order to achieve market domination in a competitive market. In my view, selection of suitable suppliers for a company is critically importance because suppliers are directly involved in the manufacturing process of any product as they supply the raw material to the company which plays its part while setting up the price for a product. Suppliers often charge different prices to the parts of the products that they supply to a company. A company should always select a supplier who should deliver the raw material and required parts of a product at an economical price to the company because it is very important for a company to set a competitive price for any product. And competitive prices can only be set up if cost of manufacturing of a product is less than then actual price of that product in the market. Ford (2002) found that the objective of selecting a suitable supplier in order to cut down the manufacturing cost of a product can be achieved by analyzing previous performances of various suppliers. Ayers (2001) found that the analysis regard ing suppliers should be based on the suppliers’ credibility, quality of the raw material that the suppliers provide to the company, and the price at which they supply the raw material. After a complete analysis, the purchasing manager should select a trustworthy and most credible supplier. Price of a product is always set up by determining the actual manufacturing cost of the product. If a company wants to achieve

Wednesday, July 24, 2019

Intellectual Property Rights Essay Example | Topics and Well Written Essays - 1250 words - 1

Intellectual Property Rights - Essay Example (Drucker). Again, other eminent writers also speak about entrepreneurship, in terms of its wealth creation abilities. Through innovation, the business creates demand for its products or services, which meets customer or market acceptance and satisfaction. This market acceptance is translated into greater demand for goods, which in turn, over a period of time, results in profits for the entrepreneurs. Thus, as the noted economist, Joseph Schumpeter has said, "from a steady economy, a technical innovation by a single entrepreneur opens up new profitable avenues - therefore, more entrepreneurs are induced to innovate, thereby increasing the profits in the economy as a whole, thereby driving growth." (After Marx: Structural Change and Steady States). This process has to be strategically dealt with, since it has serious market ramifications and could affect market positioning of competitive products, and is of importance in the ultimate success or failure of the product. The legal aspects notwithstanding, it is imperative that innovation to market creates value addition to products/services and delivers aspects or improvements on contemporary products or services. This is important, since new product should justify their position in the market and should consider issues and provide solutions that may not have been addressed by other products. Nobel laureate in economics, Ronald Coase had said that the boundaries of the firm are defined by its transaction costs. It sometimes happens that abstruse information contributes to high track costs, which in turn, leads in many instances of vertically integration. (Davenport et al 2006). Question 2: What forms of protection are available for innovation through Intellectual Property Rights. The forms of protection that are available through intellectual property Rights is in terms of the fact that the patentee enjoys exclusive rights over the patented product(s) and nobody else could seek use of such products without the prior consent of the registered patentee for a period of 20 years. However, the discretion for granting of patent lies with the Patent Office, and it is quite likely that grant of the patent could be delayed , or refused, if the concerned department is of the considered opinion that it could be detrimental to competitive products or could be perceived to enhance monopolistic trends. Financial implications of Patent registry: It needs to be said that patent registration is a financially challenging one, especially in EU countries: (McGinness 2001, P.13). From the table above it is manifest that while the total costs (excluding renewals) are a whooping 49,900 in EU countries, it is just a modest 16,450 in

Tuesday, July 23, 2019

Project Involving the Evaluation of a Website Coursework

Project Involving the Evaluation of a Website - Coursework Example The study will be divided into two different sections. First, will be the introduction of the website in regards to the 7Cs of website evaluation. This will facilitate assessment whether the choice of website is appropriate and also to evaluate the purpose of the website. The website must be able to cater for the regulation, customers’ diversity, and data protection requirements. This is why the assessments of context, content, community, customization, communication, connection and commerce are necessary. It is essential that evaluation of website meets the standard criteria. Evaluation is a process of assessing the subject in accordance to set of rules that are applicable. IKKS website assessment is not exceptional and must be evaluated as per set criteria. The second study will be founded on the Webqual 2.0, where accessibility is analyzed in details. Across the bench of 13 questions, individuals can assess the weaknesses and strengths of the website (Suh 2005).For enforcin g the website to have striking features and attract customers’ attention, it is necessary to enforce four key recommendations. First, the product may improve through bricks and clicks development, this awaits further discussion the subsequent sections. Secondly, the IKKS site ought to enhance its good judgment of society so as to award potential customers a genuine logic of corporation social responsibility. Thirdly, study and ranking of the web in accordance to the Amit and Zott forces in sequence of importance; the strategies would involve most important, 2nd most importance, 3rd most important and lastly least important. E-commerce is increasing in significance for both businesses and individuals leading to penalties for how corporations compete. Creating worth for customers that outstands the rivalry has turned into vital for firms contending through e-commerce. Business structures are generated and applied for the particular reason to contend and generate a competitive a dvantage. The website of IKKS has incorporated most of e-business requirements. Introduction Evaluating IKKS website involve assessment of the website in regard to e-business evaluation criteria.Evaluation is a methodical determination of a topic's merit, value and importance, using criteria administered by a set of principles. It can help an organization, plan, project or any extra intervention or inventiveness to evaluate any aim, realizable notion/proposal, or any option, to assist in decision-making; or to establish the level of accomplishment or value in regard to the objectives and purpose and outcomes of any such activity that has been accomplished. IKKS evaluation involves the assessments of context, content, community, customization, communication, connection and commerce. These are the 7Cs that I would use to evaluate the website (Workshop on E-Business & Wei 2002). The context of IKKS website contains aesthetic and practical feel-and-look. It is evident websites have opted to focus a lot on striking graphics, colours and invent structures, while some have accentua ted simpler utilitarian objectives, such as simplicity of scrolling. On the basis of the context, IKKS website has aesthetic, functional look and feel and utilitarian objectives. The images and graphics are attractive and the ease of navigation for more material is present (Workshop on E-Business & Wei 2002). Respective pictures within the website are navigation links to various departments or sections of the website and companies details. In IKKS website

Monday, July 22, 2019

Importance of Early Childhood Education Essay Example for Free

Importance of Early Childhood Education Essay With the economy currently in such a terrible position now it is’s no wonder why that people everywhere are being laid off, and companies around both the country and the world are jobs are laying off and choosing to keep staff to a minimum. Unfortunately, the positions that are kept are held by those who have the educational background that has essentially securedd their position from the beginning. There once was a time where an individual could apply for a job and their lack of educational experience was not held against them, but. N now, it seems as if there are extremely few reputable jobs are ooffered where only a high school diploma and some college is sufficient. But However, the economy is not who shouldto be blamed. The question instead that we should be asking that should be asked is, â€Å"where does it start? † Although it is understood that education is needed to surpass stay ahead throughout our lifeves, the importance of early education is frequently overlooked. Childhood education, as in Pre-Kindergarten thru fifth grade, is not about learning the simple or basic parts of education, but instead rather itsis about introducing young children’s minds to new and more complex things that will prepare them for a successful future. Some may choose to believe that pushing a child to learn a multitude of things at a young age would be considered cruel. Some may also believe that spending too much time learning would take away a child’s â€Å"childhood,† and that children should be allowed to stay children for as long as possible. , and should be allowed to play as much as possible. On theWhile the importance of imaginative play is alsovery important,contrary, if you were to analyzeing the circumstances it makes it would be clear as to why so many children have chosen a path of uncertainty in education. For example, take a five year old child who is being introduced to school for the first time. He or she would learn the basics; counting, coloring, reciting the ABC’s. Now take a child who has been introduced to a pre school program (normally around the age of four) as similar to that ofin First Step or Head Start. By the time that child will have entered into Kindergarten he/ or she will have already been introduced to a level of learning that is above any child that has not take advantage advantage of early learning programs. Thise will enable them to excel above their classmates. Children’s minds are truly like sponges; when a child is still young their mind’s this should be the time when their minds sshould be â€Å"crammed† with an abundance of knowledge. Sean Brotherson, a family science specialist, gives the example of a child’s brain being like a house that has just been built. He says, the walls are up and the doors are hung. You bring supplies to the new house and set them on the floor, but they will not work until everything is wired and hooked up. He goes on to explains, â€Å"wWhileexplain, â€Å"while learning later is possible, it usually is slower and more difficult. Some improvement in most skills is possible throughout life. However, providing children with the best opportunity for learning and growth during the periods when their minds are most ready to absorb new information is important†. From the time a child is born he/she is learning. A disinterest in learning at an early age is something that may follow him or her throughoutu their school age life, and is something that can haunt them for their entire lives and may hinder their ability to succeed in the real world. If a child shows no interest in adding and subtracting from the very beginning, it’s is often likely that child will continue thru school disliking Mmath throughout school. . and that This is something that can hold a child back from their potential. It also started at a young age. Children need to believe that learning is fun and, at the right age, is something that can help them progress farther. in life. In most Pre-Kindergarten classes in the United States, children are being taught to button their clothes, tie their shoes, or count to ten, and introduced to letters and shapes for the first time. These are all good tools to learn, just not in school. If you were to look at schools in other countries, they are far beyond what the U. S. is teaching our Preschoolers. Elaine Wu, with The Kapi’o Newspress, did an article on the failing education in the U. S. She found that according to a study done by UNICEF, the U. S. was failing when it came to international education rankings. Studies showed that other nations in the â€Å"developed† world had a more effective education systemsmore effective education systems. How wrong could it be to give our children a little more to think about, or giving them a problem that may take a little longer to solve?. Being that the children that attended my hHigh sSchool were approximately 75% mMilitary â€Å"brats,† it wasn’t not rare to have a new kid transfer in. There were kids from all places over the world but the ones that stood out were the ones from different countries. I took special interest in where they came from, but what interested me more was the fact that they were being placed into mostly advanceds classes. So with that curiosity I would start a conversation, usually beginning with â€Å"where are you from†? aAnd usually often times they were from another country or from somewhere where education was an important factor in their community. I am now 26 years old and am finally deciding to finish school. Things like what I just described makes me wonder about the course my life has taken. ifIf I had beenwere pushed into the books and encouraged to learn when I was younger would my outcome in school be different?. Here is another example. I look at my I have a fourteen year old nephew who is now in 9th grade. He is a straight A student and plays basketball (coincidently at my same high school). His grades are monitored by his parents but the transition wasn’t was not always easy. He came from New Orleans, Louisiana, where he lived with his mother. New , whichOrleans has one of the worst school systems in America so his early education was a struggle. When he moved to Hampton, trying to get him to open a book and study was next to impossible but. Wwith a lot of perseverance he now knows how important school is and where it can take you. But imagine if he had beenwas excited to learn from the beginning. If he had been given the opportunity, the transition may have been easier. I am now 26 years old and am finally deciding to finish school. Things like what I just described makes me wonder about the course my life has taken. If I had been pushed into the books and encouraged to learn when I was younger, would my outcome in school be different? I don’t expect society’s children to be building rocket ships at the age of eight. But putting more thought in to teaching children things that broaden their minds wouldn’t be such a bad thing. WWork Cited Brotherson, Sean. â€Å"Growth of the Mind†. Online posting. August 2001. www. nbsu. com Wu, Elaine. â€Å"Failing America†. Kapi’o Newspress. 25 April 2001 .

Two Men Destroyed by a Secret Essay Example for Free

Two Men Destroyed by a Secret Essay The characters of Oedipus from Sophocles Oedipus the King, and Torvald from Henrik Ibsens A Dolls House, while coming from two different periods in time, are in some ways very similar. Torvald and Oedipus share many qualities, such as arrogance and a fiery temper. Their lives also mirror each other in many ways. They were both prestigious well-off men with powerful positions, happy families, and everything to lose. Both men were destroyed by the revelation of a secret, which had been kept from them by their wives. Oedipus and Torvald both seem to be created by the author to have their lives shattered by a secret, and this premeditation by the author is the cause for the similarities between both the personalities and biographies of the two characters. Torvald and Oedipus share a great number of traits and flaws giving them similar personalities. Oedipus and Torvald are both arrogant stubborn men who are quick to anger and are often too curious for their own good. We are provided with spectacular evidence of Torvalds temper during the last act of the play. Torvalds explosion of anger upon the discovery of Noras secret, shows us the extent of his fiery temper. Torvalds statement, You Miserable thing, what have you done? (Ibsen, pg 104) shows us clearly the rage, which can erupt from his gentle exterior. The same blind rage is also present in the character of Oedipus. On several occasions in the play, he becomes deeply incensed and abandons his wits. This is true of his lengthy dialogue with Tiresias, the following argument with Creon, and the encounter with the Shepard at the end of the play. During this dialogue with Tiresias he remarks, Enough! I wont listen to this sort of talk from you. Damn you! My curse upon you! (Sophocles, pg 29) He is so angry that he dismisses the warning of Tiresias, failing even to consider their dire predictions. The curse he utters against Tiresias was truly a dire action since the ancient Greeks took curses much more seriously than we would today. In the play we see the fulfillment of the curse that Oedipus unintentionally brings upon himself, and from this we can gauge the seriousness of Oedipus statement. Another shared characteristic of Oedipus and Torvald is stubbornness. Oedipus stubbornness is evident in both the scene with Tiresias and the scene with the Shepard. Tiresias is unwilling to speak but (Sophocles, pg 23) Oedipus drives him to it. Oedipus is so stubborn that he ignores the warning of Tiresias, Jocasta and the shepherd not to pursue the issue of his parentage and the identity of Laius murderer. He pushes past all resistance and learns the truth to his own detriment. Torvald also is at times very stubborn. Torvald comments several times that Nora is incredibly stubborn, (Ibsen, pg 61) but it is Torvald that prevails in the battle of will that occurred over Krogstads dismissal. In this argument Torvald shows his resolve by resisting the charms of Nora, leads to the revelation of Noras secret, which shatters their marriage.

Sunday, July 21, 2019

Osmosis-Driven Protein Distribution Optimization

Osmosis-Driven Protein Distribution Optimization Osmosis-Driven Protein Distribution Optimization via a Single-Vessel Process Purpose Protein-loaded microspheres prepared via the water-in-oil-in-water (w/o/w) emulsion method are porous with poor protein distribution due to the inner water phase leaving the microspheres following polymer precipitation, resulting in the generation of cavities and large pores. Attempts to prevent this by osmosis-driven escape of the inner water phase were unsuccessful, as a polymer precipitation front formed instantly resulting in hollow microspheres. A method to tightly control the events during microsphere formation was developed. Polymer precipitation was controlled by saturating the outer water phase in the  organic solvent and isolating the secondary emulsification step from the environment to prevent organic solvent extraction prior to osmosis-driven water escape. Moreover, a single-vessel microsphere preparation method was developed to eliminate product loss and contamination resulting from multiple vessel transfers. Methods Microspheres were prepared in a single vessel, from polymer dissolution to final product storage (fig. 1). BSA-FITC, 25 kDa PLGA 50:50 and methylene chloride (DCM) were used. 0.1% w/v PVA in water was used as the outer water phase, with or without 1% w/v NaCl. The microspheres were characterized by SEM, confocal microscopy, drug loading, encapsulation efficiency, and burst release (24h) at 37oC. Results SEM and confocal microscopy revealed non-porous microspheres with homogenous distribution of protein throughout the polymer matrix when osmosis was applied, as opposed to microspheres where no osmosis was applied (Figure 2). Applying osmosis without isolating the system in a closed vial resulted in hollow microspheres. Moreover, while the application of osmosis in the preparation process did not alter significantly the drug loading or the encapsulation efficiency, the 24 h burst release decreased dramatically as shown in Figure 3. Conclusion Our results confirmed our hypothesis that isolating the system in a closed vial during the second emulsification step in combination with application of osmosis prevents early DCM extraction and polymer precipitation, resulting in non-porous microspheres with homogenous protein distribution. Protein-loaded microspheres prepared via this method showed low burst release, a significant property for controlled release microsphere systems. This work showcases the importance of excipients during microsphere preparation, as the careful choice of excipients significantly affects product quality and performance. Opalescence and Liquid-Liquid Phase Separation in a Protein Solution Purpose To study the effect of concentration, temperature, pH, ionic strength and buffer species on opalescence and liquid-liquid phase separation (LLPS) in a protein solution Methods Turbidity of a protein solution was measured as percent transmittance using UV-Vis spectrophotometer at different solution conditions. LLPS of the protein was confirmed by equilibrium studies and by visually observing LLPS under microscope. Structural changes in protein before and after phase separation were studied using Circular Dichroism. Temperature ramp studies were conducted to determine the phase separation temperature (Tcloud) at different solution conditions. Tcloud (temperature where transmittance is 70%) was correlated to protein-protein interactions measured in dilute solutions using DLS (kD). Opalescence measurements, Tcloud measurements and DLS studies were also performed in the presence of different salt ions at pH 6.5 and 15 mM ionic strength. Results For the protein molecule studied maximum opalescence is observed near the pI of the molecule and at low ionic strengths. From equilibrium studies, it was observed that protein concentration remains constant in two phases (protein-rich and protein-poor) irrespective of the initial protein concentrations. At low ionic strength and close to the pI of the molecule, Tcloud values were higher indicating a relatively less stable solution, which shifted to lower temperature values at pH away from pI. At relatively higher ionic strength, Tcloud decreased at a pH closer to pI of the molecule and increased away from pI. There was discrepancy in the magnitude of the change in attractive interactions measured by DLS and shift in Tcloud with change in solution conditions. Conclusion This study shows that phase separation is an equilibrium/thermodynamic process; protein does not undergo structural changes on phase separation. Strong attractive interactions are observed in systems exhibiting LLPS as indicated by shifts to higher Tcloud and large negative kD. Tcloud measurements can be utilized as a potential screening tool to study the effect of excipients on opalescence and phase separation in early stages of protein formulation development. A Detailed Mechanistic Study on Adjuvants and Optimizing Antigenicity of Particulate Cancer Vaccines Purpose Sperm protein 17 (Sp17) is a cancer/testis antigen which is expressed aberrantly in several cancers like prostate, ovarian cancer, hepatocellular carcinoma and multiple myeloma. Its restricted expression in normal tissues and aberrant expression in cancers makes it an attractive target for cancer immunotherapy. Enhancing delivery of Sp17 may significantly improve clinical outcome by eliciting a specific and sustained anti-tumor response. The main goals of this project were 1) to formulate Sp17 microparticles (MP) and investigate its efficacy in vitro. 2) Conduct a detailed mechanistic study on adjuvants that may augment anti-tumor efficacy of Sp17 MP. 3) To test combination of two adjuvants in conjunction with Sp17 MP for synergetic effect Methods Recombinant Sp17 was expressed in M15 cells, isolated and purified using the Ni-NTA fast start kit (Qiagen). Sp17 and adjuvants were encapsulated separately in MP using the Buchi B-290 spray drier. Particle size, zeta potential and SEM imaging was performed on microparticles. SDS-PAGE was performed to confirm the stability of Sp17 in MP. Release of Sp17 from MP was performed in gastric and intestinal pH conditions. Eight adjuvant MP were screened on DC 2.4 cells by studying several innate and adaptive immune markers like nitric oxide, CD40, CD80, CD86, CD54 and MHC-II. Results Sp17 MP had an average particle size of 3.59  ± 0.5ÃŽ ¼m and zeta potential of +9.36mV. Encapsulation efficiency of Sp17 was found to be 78%. SEM images confirmed particles were irregular in shaped with surface indentations. SDS-PAGE confirmed the presence of Sp17 encapsulated in its native form. Cumulative release of Sp17 was approximately 15% in simulated murine gastric and intestinal pH conditions. Nitric oxide release was significantly (p compared to Sp17 MP. Combination of R848 and Alum, R848 and MF59 and R848 and P4 showed enhanced expression of CD80. CD40 elevation was highest in MPL and R848 combination. Conclusion Sp17 MP in combination with R848, MPL and MF59 MP significantly improve innate and adaptive immune response to cancer antigens. In Vitro and In Vivo Studies on Transdermal Particulate HPV Vaccine Purpose Human Papillomavirus (HPV) vaccines are recommended by the World Health Organization for cervical cancer control programs world-wide. However, the cost of these vaccines and requirements for administration are significant barriers for vaccination in developing countries. Microparticulate vaccines have the potential to alleviate these problems. The purpose of this study is to develop an HPV16 microparticulate vaccine for transdermal administration and evaluate its efficacy in both in-vitro and in-vivo studies. Methods HPV 16 virus-like particles (VLPs) were produced in human embryonic kidney cells 293TT. VLPs were incorporated into a cellulosic polymer matrix and formulated into microparticles using a Buchi B-290 spray dryer in a single step. VLP encapsulation was determined using transmission electron microscopy (TEM) and Western blot analysis. For in–vitro study, antigen-presenting cells (APCs) were exposed to vaccine and characterized for cell-surface expression (CD40, CD80/86 and MHC II). For in-vivo study, AdminPatch ® transdermal administration of VLPs as microparticles was compared to VLPs in solution. Female BALB/c mice (n=6 for each group) received 4 doses. Blood samples were collected and antibodies were detected with a direct HPV16 VLP IgG ELISA. Spleen and lymph node pools were prepared at week 40 to analyze memory T and B cells using flow cytometry. Results The microparticle yield after spraying was 90% w/w, with average size 3.5+ 0.6 ÃŽ ¼m and average zeta potential -19.7 + 0.3 mV. VLP encapsulation efficiency was 85% based on Western blot detection of HPV16 L1 protein. APCs expressed significantly higher CD40, CD80/86 and MHCII in the particulate vaccine group compared to the solution group. HPV 16 antibodies were detected more frequently in the microparticle group (3 of 6 mice by week 7 and 6 of 6 mice by week 12) than in the solution group (1 of 6 mice by week 12). Spleen and lymph node CD4+, CD27, CD62L and CD45R cell populations were significantly higher (p Conclusion Transdermal administration of HPV VLP as microparticulate vaccine is more immunogenic than HPV VLP in solution. Phase Separation and Component Crystallization in Freezing Segment of Protein and Amino Acid Lyophilization Purpose Many freeze-dried protein formulations contain glass-forming stabilizing excipients (e.g., trehalose) that protect proteins from dehydration-induced irreversible conformation changes and chemical changes during storage. Some amino acid excipients also form glass-state solids upon lyophilization. The purpose of this study was to elucidate miscibility of proteins and amino acid excipients in frozen solutions and its effect on their crystallization. Methods Aliquots of frozen solutions containing a model protein (e.g., recombinant human albumin) and amino acids were applied for heating thermal analysis from -70 °C to obtain glass transition temperatures of maximally freeze-concentrated solutes Tgà ´Ã¢â€š ¬Ã¢â€š ¬Ã¢â€š ¬OEand solute crystallization peaks. Some frozen solutions were annealed at elevated temperatures (e.g., -10 °C) before their second scan from -70 °C. Results Some amino acid excipients (e.g., L-valine, glycine) showed high propensity to crystallize during the freezing process. Other excipients freeze-concentrated into narrow non-ice regions between ice crystals remained amorphous (e.g., sodium Lglutamate, L-arginine hydrochloride) or crystallized (e.g., L-histidine hydrochloride) upon the annealing. Frozen solutions containing the protein and amorphous excipients showed single or double Tgà ´Ã¢â€š ¬Ã¢â€š ¬Ã¢â€š ¬OE transitions that indicate their varied miscibility depending on the combinations and concentration ratios. Many protein-rich frozen solutions showed single Tgà ´Ã¢â€š ¬Ã¢â€š ¬Ã¢â€š ¬OE transitions in the first heating scans and after their annealing, indicating maintenance of the amorphous concentrated solute mixture. Frozen solutions containing rHA and higher mass ratio of L-Arg HCl showed double Tgà ´Ã¢â€š ¬Ã¢â€š ¬Ã¢â€š ¬OE transitions. The transition temperature profiles suggested separation of the non-crystalline solutes into the solute-mixture and excipient phases. Frozen solutions containing rHA and higher mass ratio of L-His HCl showed the amorphous/amorphous phase separation and following crystallization of the excipient. Conclusion The phase separation should allow nucleation of amino acid crystals in the excipient-dominant concentrated phase. Information on the solute mixing state should be valuable for appropriate use of the amino acid excipients either as a crystalline bulking agent or an amorphous stabilizer in freeze-dried formulations.

Saturday, July 20, 2019

Shakespeares King Lear - Father/Son Conflicts Caused by Inferiority Complex and Power Struggle :: essays research papers

Throughout the play King Lear, by William Shakespeare, a conflict is conveyed through father and son: Gloucester and Edmund. Although the cause of this conflict is Gloucester’s betrayal by his bastard son, Edmund, there is more to this conflict than a simple power struggle. Through intertwining plots and scandals, Edmund creates a forged letter, destructively â€Å"written† by his half-brother, Edgar, having to do with his made up plans to murder his father, Gloucester. Edmund surpasses this first betrayal and reaches the epitome of evil when he plots against his father by finding ways to cross Gloucester with Regan and Cornwall, further enhancing his potential inheritance and power. In this conflict, Edmund is the ultimate cause and initiator, making his father a victim to the scandal Edmund has viciously created. The conflict between Gloucester and his contriving son contribute to King Lear by becoming a parallel between Lear’s problems with his own daughters. Lear finds himself in a similar situation, his two daughters, Regan and Goneril, also scheme to betray their father, with hopes to profit from his loss of power. The resemblance between Lear’s daughters and Edmund holds a purpose to enhance the reader’s perception of what conflicts the desire for more power can create. Only through conveying separate instances of incredible treason between parent and offspring can the meaning and truth within the play’s key theme of betrayal be expressed. Shakespeare creates the character of Edmund to be the perfect villain. Not only does he â€Å"fight dirty† to gain power, he does it through manipulation and a complete lack of a conscience throughout a majority of the play. Because he is the illegitimate child he plans to, â€Å"if not by birth, have lands by wit.† The conflict between him and Gloucester is simply an inevitable effect caused by Edmund’s unyielding desire to gain more than his bastard status affords. He basically rips the Earl title away, along with his father’s eyes because of his unstoppable ambition. It is precisely this power-hungry vigor that Edmund maintains throughout the play that stirs the conflict with his father, enhancing the main plot of the betrayal of Lear by his duplicitous daughters. Edmund becomes increasingly consumed with the idea of gaining power and losing the bastard status that has been tagged to him since birth.

Friday, July 19, 2019

Women changing From Hellenistic to Late Antiquity Essay -- essays rese

The world is constantly changing and evolving. In every society across the world, men and women have specific roles that they each carry out. During ancient times, in most western cultures, women were inferior to men. Women’s status seemed to change in a pattern that repeated it self from one time period to another. Gradually, the status of women did change from political standpoints of the societies. From political power to having the right last name, women have transformed and became a huge part of Western Civilization. During times of Hellenic Greece, women were considered naturally weaker than men, squeamish, and unable to perform work requiring muscular or intellectual development. In most Hellenic societies, for example, domestic chores were delegated to women, leaving heavier labors, such as war and hunting, to men. Women also have generally had fewer legal rights and career opportunities than men. From the text from Kilshansky, The Spartan Constitution, Lycurgus believed that motherhood is the most important function of freeborn woman. Lycurgus then insisted on physical training of the females along with the males. Lycurgus also believed that to have future success is to have a strong youth. The Hellenic times were like this for the sole reason that few elite men ruled. With these men in control, it was made possible that no woman could ever have a say in the government of Sparta or the democracy of Athens. When the Hellenistic Kingdoms started to spur, new opportunities for women appeared. Levack stated that, â€Å"Greek women in Egypt, as well as many other Hellenized land, enjoyed full citizenship and held religious offices.† This simply shows that the women of the middle class had new privileges, but what about the women... ...though the wives or daughters of wealthy and powerful families could work with other women of society. For example Melania the Younger, the daughter of a wealthy roman senatorial family, decided to dispose her property. The senate, who, I might add, was all male, objected to the breaking up of Melanie’s family estates. Melania then appealed to the empress, a female leader, and the senate was overruled, allowing Melania to break up her estates. This is just one example of how political power can change the status of women dramatically. Based on these facts on how women gradually promoted themselves into freedom, some factors clearly changed the way people viewed women in their societies. From having political power in the family to being persuasive in other areas of life, women came from being a housewife to a possible empress during the civilization of the west.

The Roles of Greek Heroism and the Gods in the Persian Wars Essay

The Roles of Greek Heroism and the Gods in the Persian Wars The Persian Wars (499-479 BC) put the Greeks in the difficult position of having to defend their country against a vast empire with an army that greatly outnumbered their own. Many city-states united in battle, although others found ways to avoid participation in the wars. The Greeks also relied on the words of Apollo to guide them, but the oracle did not always act encouragingly. The Greeks defeated the Persians in the Persian Wars due to heroic actions performed by Athens and Sparta and occasional assistance from the gods, but cowardice shown by other poleis nearly ended the Greeks’ chances of success. Unity between the Greek poleis could be seen occasionally in the battles of the Persian Wars, but not consistently. The Greeks first confronted the Persians during the Ionian Revolt (499-494 BC). Ionian Greeks wanted to escape the oppressive system the Persians had them under, so they turned to the Athenians. They in turn offered 20 ships to the revolt, and the Eretrians offered five ships (Demand 1996: 184). Although the revolt was unsuccessful, the help offered by Athens and Eretria provided the first instance of unity among several Greek poleis. The Battle of Marathon in 490 BC, however, did not provide such an instance. When the Persian army headed to Greece to attack, only Athens and Plataea sent soldiers to fight them. The Spartans claimed they could not send soldiers due to a festival and only appeared after the battle was won by the Athenians and Plataeans to congratulate the victors (Demand 1996: 186-187). The victory gave a boost to the confidence of the Athenians, who felt that â€Å"at Marathon we were the only ones to face up to th... ...arta to play greater roles in battle. This produced a tension between the city-states that nearly allowed the Persians to claim victory. The Greeks turned to Apollo, but the oracle did not encourage them. The Greek forces continued to fight, however, driven by acts of bravery performed by Athens and Sparta. Though the Greeks did not achieve complete unity or receive absolute encouragement from the gods, they had enough bravery and faith to bring them success in the Persian Wars. Works Cited Crane, Gregory R. (ed.) The Perseus Project, http://www.perseus.tufts.edu, November, 1998. Demand, Nancy. A History of Ancient Greece. New York: The McGraw-Hill Companies, Inc., 1996. Dillon, Matthew, and Lynda Garland. Ancient Greece: Social and Historical Documents from Archaic Times to the Death of Socrates. London: Routledge, 1994. No. 7.42, p. 209.

Thursday, July 18, 2019

Heraldic Code of the Philippines Essay

â€Å"Don’t walk in front of me, I may not follow; don’t walk behind me, I may not lead; Just walk beside me, and be my friend†. I have one such good friend who walks beside me and who extends his hand, when I am about to slip and fall. He is my greatest asset in life, which I treasure more than anything else in this world. He is my best friend. My best friend is Tom Sangma. We come from the same neighbourhood. Our houses are situated close to each others. Both Tom and I are of same age and belong to more or less same economic background. In fact, what has cemented our friendship deep is that our families have been close to each other for a long time. My father and his father were classmates. My mother’s best friend is Tom’s mother. Another reason, which probably helped us to become good friends, is that we have grown together. We have spent our childhood days playing, fighting, learning, and enjoying together. My memory of sweet bygone days of the past is a nostalgic memory of happy days spent together in Tom’s company. Today Tom and I study in Class X in a reputed school in the town. We generally go to school together and have been lucky enough to be studying in the same class for the past ten years and more. Tom has many excellent qualities of heart and mind. His simplicity, smartness, neatness, intelligence, straightforwardness, cool temperament, pleasant behaviour, gentle ways, dutifulness, etc. have made him one of the most liked and popular students in the school. Tom’s sweet temperament is his greatest quality. He never hurts others or speaks ill of others. He has a charming personality. For several years consecutively, he has been given the ‘Best Student’ award in the school. Despite my best efforts I have never managed to reach his level. Yet I never feel jealous of him. Because he helps me more than anybody. He tries to do all he can to make me come up to his level. He never goes to any function or party or film without me. I do the same for him. Whenever I am sick, he is the first to come and see me. There is no function in my home without his presence. The same is true in his house as well. All these have combined to make our friendship deep and lasting. The best trait that I admire and like most in my friend is his disciplined life. He would not do anything that goes against accepted norms or decency. He gets up on time, does his homework always, attends school regularly, respects his teachers and elders and never indulges in unhealthy ways such as, smoking, taking alcohol, idling away time, skipping classes etc. His principle of ‘duty first- enjoyment second’ is something that I find difficult to follow, yet try to imitate. He corrects me whenever I commit any mistake. For me he is a source of inspiration, support and also a role model to imitate. I am ever grateful to the almighty for having given me such a good friend. I cherish it as my greatest treasure. I am sure our friendship will grow deeper and deeper in the years to come. I wish everyone had such friends in life. One cannot describe the thrill and the joy of journeying together in life, sharing its ups and downs, rainbows and thunders and Good Fridays and Easters. It has to be experienced.

Wednesday, July 17, 2019

Deputy Manager Essay

The assimilator will1. gain transmutation, equality and cellular inclusion body body body body in own ambit of certificate of indebtedness Assessment criteriaThe bookman end1.1 condone models of practice that underpin equality, mutation and inclusion in own neighborhood of indebtedness1.2 collapse the potential effects of barriers to equality and inclusion in own heavens of responsibility1.3 Analyse the impact of decree and insurance initiatives on the promotion of equality, diversity and inclusion in own area of responsibility teaching outcomeThe assimilator will2. Be able to support diversity, equality and inclusionAssessment criteriaThe pupil can2.1 Promote equality, diversity and inclusion in policy and practice 2.2 gainsay discrimination and projection in policy and practice 2.3 Provide others with information mostthe effects of discriminationthe impact of inclusionthe value of diversity urban center & Guilds take aim 5 Diploma in leading for health a nd social rush and children and fresh peoples function (England) (3978-51/52/53/54/55/56)2.4 sponsor others to challenge discrimination and exclusionLearning outcomeThe learner will3. Understand how to develop systems and processes that promote diversity, equality and inclusionAssessment criteriaThe learner can3.1 Analyse how systems and processes can promote equality and inclusion or reinforce discrimination and exclusion3.2 Evaluate the effectiveness of systems and processes in promoting equality, diversity and inclusion in own area of responsibility3.3 calculate improvements to address gaps or shortfalls in systems and processesLearning outcomeThe learner will4. Be able to fare the risks presented when equilibrise individual rights and professional job of keepingAssessment criteriaThe learner can4.1 Describe ethical dilemmas that whitethorn burn up in own area of responsibility when balancing individual rights and duty of care4.2 Explain the principle of informed pickax 4.3 Explain how issues of individual capacity may affect informed choice4.4 Propose a strategy to manage risks when balancing individual rights and duty of care in own area of responsibilityCity & Guilds Level 5 Diploma in Leadership for health and social care and children and young peoples services (England) (3978-51/52/53/54/55/56)

Tuesday, July 16, 2019

Coke Zero Essay

Coke Zero Essay

Coke Zero is the latest new product in the marketplace for hot coke and it appears that it is a success since it is.Coke Zero old has the word â€Å"zero† in it which already musical sounds a lot better than â€Å"Diet Coke† or â€Å"Diet metallurgical Coke Plus†. â€Å"Coke Zero† is straight to the point logical and automatically has the potential customer wishful thinking he (or she) free will not be consuming any calories.2. Why do you think that the hidden-camera educational videos used to promote Coke Zero were an effective way to reach based its target market? Do you many think a similar strategy with a viral marketing political campaign on the Internet would appeal to the main target market for Diet metallurgical Coke Plus?I think the hidden cameras were a good idea, but not completely original.Its something which a larger whole lot of soda drinkers good will be sad to go, logical and some of them are currently freaking worn out about it.Coke No Sugar, because the title implies, what does not include any sugar.

Diet cold sodas arent neutral since they just have photographic negative side effects and they provide no nutrition in return.Coke earns better economic gains than Pepsi due to the international marketing and promotion strategies.Faced with domestic market share, Coke began a collection of new its own internal flavor tests.Coke is among the brands deeds that are worldwide that are clinical most effective.

The customer perception couldnt alter logical and also make it few more appealing for men.Utilizing Demographic segmentation empty can truly help make or complete break a item.The item was targeted to many women who should get rid of weight logical and are worried about health logical and nourishment that is sex segmentation.The important distinction is the way they taste, due to the recipes.

Monday, July 15, 2019

Funny in Farsi Analysis

homophile(a) in Farsi digest Firoozeh Dumas is an Iranian-the Statesn writer, cognise for creating the memoir shady in Farsi. innate(p) in Iran, Dumas regulates of her puerility memories and how she and her family go to America when she was just when cardinal historic period old. shortly afterward the thus removedts that took daub on folk 11th, friends had boost her to say the stories that she had written. By doing this, she would be fit to tell Ameri shtups of how pump east cultures atomic number 18 non what the media portrays them to be.Throughout the memoir, Dumas aims to confront Ameri thrones that Iranians ar rattling double-dyed(a) and fuddle a champion of inclination. With the hold of light snappishness, mad raise, and family recitals, Dumas lay outs that Iranians ar not, (in both way,) what we consider they argon. Dumas attempts to utter us that Iranians arrest a sense opinion of mode by establishing a cheerful opinion from th e pedigree of the art scarcet. As argue to retentiveness the piece serious, she ends the really starting lineborn departure aphorism that even so though her chum was far out-of-door from her it was and a teensy hurt to endure for owning a Barbie.Though she could pay off been commission on the outdistance from her br anformer(a)(prenominal), she was kind of occupied with her Barbie, an spell sanely normal for a seven-year-old girl. The verbiage can service of process galore(postnominal) referees intuitive feeling nostalgic. legion(predicate) mint shake up somewhat riddle of object or victimize bind to a relative, and creation with that fussy dally can secure it bet as if we argon with that love one. At the compar suitable judgment of conviction, this in any case sparks stimulated appeal and nostalgia to the reader some of us, as children had strand ourselves riant at the pass on of a smart toy, even if we had been crying(a) labo redly seconds before.Dumas intimately calls both strategies at the same time to show the ingenuousness and humor of tenderness eastern cultures. later a rather ungainly frontmost twenty-four hour periodtimetime of indoctrinate (with her yield,) Dumas distinguishable that from that solar twenty-four hour period on, her scram would wear to wait internal. Dumas practice sessions a gang of a family anecdote as well as self-deprecation to subject the whiteness and humor of the centre of attention easterly good deal. Dumas attends her rattling prototypical day of naturalize with her fix to. The day proves to be muggy to Dumas, as it negated the imagination she had do unspoilt the other day.The students had begun to look at them not because they could not give tongue to English, but because they appeared rather dimwitted. The creator belittles herself by the use of self-deprecation because of this, the earreach is able to account with her. Dumas does this successfully by admitting that she and her mother appeared paradoxical, pass on reinforcing it by reflection that her first impression had been negated by the days events. The word of honor negated communicates the vagary that Dumas hard spend a penny in impressing her teacher, Mrs. Sandberg had been make in vain.It makes her more than appealing to her readers, and only strengthens her subject matter that Iranians are save inoffensive and meek wad. The folk 11 attacks had leftfield galore(postnominal) kernel east cultures with wondrous stereotypes. Dumas memoirs, however, successfully go the characterization that substance eastern people are not what the media tells us. With the use of a light aroma and Dumas jesting narration of button to give lessons and owning Barbies, risible in Farsi shows the earshot that the Iranian people (and by chance other mediate eastern cultures,) are thusly innocent, virtuous, and secondary people.